Endocrine Abstracts

Melanocortin receptors (MCR), which belong to the superfamiliy of G protein-coupled receptors (GPCR), are preferentially coupled to Gs proteins and play a major role in the regulation of energy homeostasis. In line with this notion, mutations in the MC4R gene are the most frequent monogenic cause of severe obesity in human beings. Recently it has been shown that the MC4R receptor undergoes, similar to most GPCR, GPCR kinase (GRK) and arrestin-mediated ligand-promoted receptor ...